Lactic acid

Research use only, not for human use.

Lactic acid (2-hydroxypropanoic acid) is a product of glycolysis and is widely found in nature.Lactic acid is produced in the body during hypoxia in contracted skeletal muscle and can be removed under fully aerobic conditions.

Lactate (Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactate is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactate is an oncometabolite and has immune protective role of lactate in anti-tumor immunity.

Cell Proliferation Assay Cell Line:Uveal melanoma 92.1 cells Concentration:20 mM Incubation Time:24, 48 h Result:Inhibited cell proliferation and migration.Western Blot Analysis Cell Line:Uveal melanoma cells Concentration:20 mM Incubation Time:24 h Result:Showed an increase in the protein expression levels of MCT1 and HCAR1 Western Blot Analysis Cell Line:Uveal melanoma cells Concentration:20 mM Incubation Time:24 h Result:Induced a significant increase in mRNA expression levels of SLC16A1 and HCAR1.

Animal Model:Female C57BL/6 mice with MC38 colon cancer cells Dosage:1.6 g/kg Administration:Subcutaneous; daily from Day 8 to 30 days Result:Significantly suppressed tumor growth.

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Others

Other Targets

Others

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50-21-5

90.08

C3H6O3

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (1110.12 mM; Ultrasonic) DMSO : 100 mg/mL (1110.12 mM; Ultrasonic )

CC(O)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years